WebSignal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH), Src homology 2 (SH2)-like domains, and proline-rich … WebSignal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation. Oncotarget. 2024; 8: 30766-30780. Crossref; PubMed; Scopus (7) Google Scholar]. STAP-2 can also bind to FcεRI, which is expressed in mast cells and basophils [46. Sekine Y ;
Pivotal Role of Signal-Transducing Adaptor Protein-2 in ... - PubMed
WebDec 31, 2012 · Fms-like tyrosine kinase 3 (Flt3) is an important growth factor receptor in hematopoiesis. Gain-of-function mutations of the receptor contribute to the transformation of acute myeloid leukemia (AML). Src-like adaptor protein (SLAP) is an interaction partner of the E3 ubiquitin ligase Cbl that can regulate receptor tyrosine kinases-mediated signal … WebMar 29, 2024 · Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases. These findings indicate an essential role for STAP2 in the generation of a high … darty chateaubriant
Signal-transducing adaptor protein-2 has a nonredundant …
WebOct 19, 2024 · Gαi1/3 is associated with EGF-stimulated EGFR and the adaptor protein Grb2-associated binder 1 (Gab1) to transduce downstream Akt-mTOR activation (Cao et al., 2009). Gαi1/3 are key signaling proteins of vascular endothelial growth factor (VEGF) signaling and are essential for VEGF-induced VEGF receptor 2 (VEGFR2) endocytosis, … WebMar 21, 2024 · STAP2 (Signal Transducing Adaptor Family Member 2) is a Protein Coding gene. Diseases associated with STAP2 include Trichothiodystrophy 1, Photosensitive and … WebDefinition. Adaptor proteins are multi-domain proteins (Fig. 1) that interact with components of signaling pathways [ 1 ]. As a consequence of these interactions, adaptor proteins are able to regulate signaling events within the cell, providing spatiotemporal control and specificity, and influencing how a cell responds to a particular stimulus. bistro the meat 新宿本店