Rbm38 in cancer: role and mechanism
WebJul 24, 2024 · This mechanism is similar to eIF2 alpha phosphorylation ... (Gerlitz et al., 2002; Tinton et al., 2005) or cleavage of scaffolding need to increase our understanding on the role of sequences and ... RNA unique RNA binding domain indicated as a K-homology domain binding motif 38 (RBM38) is an RBP that is ... WebHepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Recent studies reported that lncRNA LINC00473 (LNC473) was involved in cancer progression. However, the clinical significance and functional role of LNC473 in HCC progression is still unknown. In the present study, we found that the LNC473 expression ...
Rbm38 in cancer: role and mechanism
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WebSep 1, 2012 · Abstract. The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes and is a critical downstream target of the tumor suppressor pRB. The pRB/E2F pathway is defective in most human tumors, resulting in deregulated E2F activity that induces uncontrolled cell proliferation, a hallmark of tumor … WebApr 12, 2024 · An inducible mouse model of colonic cancer was founded using AOM + DSS treatment to investigate the roles of exogenous 5-HT in the carcinogenesis of colon cancer. After 90 days of treatment with 10 mg/kg 5-HT (Fig. 5 A), the tumour number and volume in the mice’s intestinal mucosa were 11.60 ± 1.52 and 14.35 ± 2.72 mm 3 , respectively.
WebApr 11, 2024 · Background Hypoxia-inducible factors (HIFs) are the most essential endogenous transcription factors in the hypoxic microenvironment and regulate multiple genes involved in the proliferation, migration, invasion, and EMT of hepatocellular carcinoma (HCC) cells. However, the regulatory mechanism of HIFs in driving HCC progression … WebOct 25, 2011 · RBM38 in cancer: role and mechanism. 08 July 2024. Cheng Zou, Ying Wan, ... and wt p53 status, suggesting a tumour suppressive role of RBM38 in breast cancer . ...
WebJul 8, 2024 · The evidence that RBM38, an intensively studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types is reviewed and the possibility of … WebMar 15, 2024 · Cancer cells are known to adapt a few alternate pathways to maintain cellular iron balance. In NSCLS (non-small cell lung carcinoma cells) EGFR, growth factor that regulates growth, survival, proliferation and differentiation in mammalian cells has been demonstrated to affect iron metabolism by directly binding and redistributing TfR-1 [41,44].
Web10 hours ago · AR plays a critical role in the development and progression of prostate cancer, particularly in its metastatic form. AR is a transcription factor, which means it …
WebSep 3, 2024 · Deactivation of RBM38 could disrupt p53-mdm2 loop function and promote HCC, but its role and molecular mechanism remain scanty and contradictory. In the … on men\u0027s cloudswift running shoeWebSep 3, 2024 · In the present study, we investigated the role and molecular mechanism of RBM38 as a tumor suppressor to prevent HCC via stabilizing the p53-mdm2 loop … on men\\u0027s cloudgo running shoes reviewshttp://lcgdbzz.org/en/article/doi/10.3969/j.issn.1001-5256.2024.04.032 on men\\u0027s cloudswift sneakersWebThe present disclosure provides methods for increasing the quantity and/or the ratios of erythroblasts, reticulocytes, and/or erythrocytes, or progenitors thereof, in which any of these cells express HbF (e.g. HbF + and/or HbF high cells). The present disclosure further provides methods for treating diseases or disorders characterized by, for example, oxygen delivery … on men\u0027s cloudrunner running shoesWebThe RNA-binding protein Rbm38 is dispensable during ... Somatic mutational landscape of splicing factor genes and their functional consequences across 33 Cancer types. Cell Rep. 2024; 23: 282 ... a subset of patients with end-stage heart failure may represent a starting point for future studies to elucidate their role and mechanism in the ... in what ways do we hear the voice of godWebHepatocellular carcinoma (HCC) is the most common type of liver cancer in China, and the development and progression of HCC is a complex pathological process. As a new way of cell death, ferroptosis has huge potential in the treatment of HCC. This article introduces the mechanism of action of the tumor suppressor p53 in regulating ferroptosis and briefly … on merchWebSep 29, 2011 · This review highlights a decade of investigations into the role of CD38 in CLL. An association between CD38 expression by CLL cells and a more aggressive clinical behavior was first reported in 1999 4 and confirmed by several subsequent studies. 8-12 Consequently, determination of the percentage of CD38-expressing cells within a clone … in what ways do people change earth\u0027s systems