Ppgpp: magic beyond rna polymerase
WebFeb 16, 2012 · ppGpp: magic beyond RNA polymerase The bacterial signalling nucleotide ppGpp is known to regulate promoter selection by RNA polymerase to direct the response to stress. WebStill looking for the magic spot: the crystallographically defined binding site for ppGpp on RNA polymerase is unlikely to be responsible for rRNA transcription regulation. Journal of …
Ppgpp: magic beyond rna polymerase
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WebAfter a brief overview of ppGpp biosynthesis and its impact on promoter selection by RNAP, we discuss how bacteria exploit ppGpp to modulate the synthesis, stability or activity of … WebJun 23, 2024 · First, (p)ppGpp affects synthesis of ribosomal proteins and RNAs in Escherichia coli at least in part by inhibiting RNA polymerase . Second, studies examining the effect of (p)ppGpp produced by RelA …
WebJan 20, 2015 · ppGpp: magic beyond RNA polymerase. Nat Rev Microbiol 10:203–212. doi: 10.1038/nrmicro2720. [Google Scholar] 8. Ross W, Vrentas CE, Sanchez-Vazquez P, Gaal T, Gourse RL. 2013. The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation. Mol Cell 50:420–429. doi: … WebppGpp was discovered as a ‘magic spot’ on thin-layer chromatograms that were designed to analyse changes in cellular nucleotide pools in response to nutrient stress.
WebMay 13, 2024 · In contrast to RelA, SpoT is also able to hydrolyze (p)ppGpp to produce GTP or GDP and inorganic phosphate. ppGpp binds to RNA polymerase with DksA to modulate transcription, and to effector proteins to regulate their biochemical activity. WebDec 1, 2024 · The targets of (p)ppGpp have expanded beyond RNA polymerase in E. coli (Zhang et al., 2024). As discussed before, in B. subtilis , purine nucleotide biosynthesis enzymes have been reported to be the primary target and not RNA polymerase ( Kriel et al., 2012 ). p)ppGpp is a highly charged species with structural similarity to its precursor (GTP …
WebSince then, extensive genetic and molecular analyses in Escherichia coli have established that ppGpp alters transcription globally by regulating RNA polymerase (RNAP) activity …
http://www.sciepub.com/reference/141278 grease coming out of bearingsWebMay 1, 2005 · ppGpp binds to the β and β′ subunits of the RNA polymerase (RNAP) core enzyme 4, 5, 6 and affects a plethora of physiological activities, the main target being transcription. In addition to its role in repressing rRNA synthesis the alarmone ppGpp can also act as a positive effector of gene expression and a large number of σ 70 -dependent ... chong wang pfizerWebFeb 16, 2012 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J chong wai thengWebMay 9, 2013 · The global regulatory nucleotide ppGpp ("magic spot") regulates transcription from a large subset of Escherichia coli promoters, illustrating how small molecules can … grease common sense mediaWebGale Academic OneFile includes ppGpp: magic beyond RNA polymerase by Zachary D. Dalebroux and Michele S. Swanson. Click to explore. Use this link to get back to this page. chong wai theng vitalWebApr 10, 2024 · The second messenger nucleotide ppGpp dramatically alters gene expression in bacteria to adjust cellular metabolism to nutrient availability. ppGpp binds to two sites on RNA polymerase (RNAP) in … grease coming out of back of spindle trailerWebApr 10, 2024 · The second messenger nucleotide ppGpp dramatically alters gene expression in bacteria to adjust cellular metabolism to nutrient availability. ppGpp binds to two sites … chong wang perimeter