WebFeb 1, 2016 · Principles of prescribing. Renal impairment reduces the clearance of some drugs. 4 When prescribing for patients on dialysis, it is essential to consult a reference … WebNational Center for Biotechnology Information
Palliative and end-of-life care in advanced renal failure - PMC
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Continuous venovenous hemodiafiltration for renal failure …
WebObjective: We describe a case of morphine toxicity presumably caused by accumulation of its active metabolite morphine-6-glucuronide (M6G) secondary to reduced clearance by … WebAug 20, 2014 · Pharmacologic Approach in Renal Impairment and Dialysis. Morphine: Morphine, which was invented in 1804, is among the oldest and most studied drugs … WebOct 9, 2014 · It is hepatically metabolized via cytochrome P450 (CYP450) to codeine-6-glucuronide, norcodeine, morphine (approximately 10%), M3G, M6G, and normorphine.³⁸ Guay et al found that codeine and its metabolites had significantly longer half-lives in patients on hemodialysis.³⁹ The normal half-life of codeine’s major metabolites is … crossfit hsp