Web14 mei 2024 · CRISPR-Cas9-mediated deletion of H19 caused downregulation of miR-675 and facilitated CML cell death upon IM treatment especially in IM-resistant cells, while … Web15 apr. 2016 · HuR overexpression prevented the stimulation of miR-675 processing from H19, promoted ZO-1 and E-cadherin production, and abolished H19-induced …
Oncofetal H19-derived miR-675 regulates tumor suppressor RB in …
WebOverexpression of HuR alone caused a moderate increase in p53 expression (Fig. 1C). However, there was no significant change in p53 mRNA level either on miR-125b or … Web12 okt. 2024 · The mechanistic analysis showed that TUG1 positively regulated the HuR/c-myc axis via its interaction with HuR, leading to upregulation of c-myc expression; meanwhile, TUG1 negatively regulated the miR-29b-3p/CDK2 signaling via binding to miR-29b-3p, leading to derepression of CDK2 expression. make her fall in love with me
MiR-675 is frequently overexpressed in gastric cancer and …
Web19 nov. 2009 · Suppression of miR-675 by transfection with anti-miR-675 increased RB expression and at the same time, decreased cell growth and soft agar colony formation in human colon cancer cells. Reciprocally, enhanced miR-675 expression by transfection with miR-675 precursor decreased RB expression, increased tumor cell growth and soft agar … Web1 aug. 2024 · The RNA binding protein HuR bound to full-length H19 in the region of the miR-675 stem-loop to inhibit miR-675 processing, without disturbing the abundant expression of H19 (Keniry et al., 2012). Dynamic regulation of the release of miR-675 by … WebIncreasing the level of the RNA-binding protein HuR in cells overexpressing H19 prevented the stimulation of miR-675 processing from H19, promoted ZO-1 and E-cadherin … make her love you telepathy