site stats

Clec2 family

WebCLEC2 family members have broad tissue expression, with LLT1, AICL and KACL expressed on B cells, monocytes, and keratinocytes, respectively (3-5). In contrast, CLEC2L, a homodimeric cell surface receptor, is predominantly expressed in the brain and is referred to as the brain-associated C-type lectin (BACL) (6). Mature human CLEC2L … WebJan 5, 2015 · CLEC2 is also a receptor for the endogenous platelet activator podoplanin (PDPN; 608863). Using protein binding experiments, Suzuki-Inoue et al. (2010) found …

CLEC2A: a novel, alternatively spliced and skin-associated member …

WebC-type lectin domain family 1 member B (UniProt Q9P126; also known as C-type lectin-like receptor 2, CLEC-2) is encoded by the CLEC1B (also known as CLEC2, UNQ721/PRO1384) gene (Gene ID 51266) in human. CLEC-2 is a type II single-transmembrane (a.a. 34-54) protein with a large extracellular (a.a. 55-229) region that … WebJun 3, 2024 · CLEC5A and CLEC2 are spleen tyrosine kinase (Syk)-coupled C-type lectin receptors, abundantly expressed by leukocytes and platelets, respectively. Whereas CLEC5A is a pattern recognition receptor... effeminate used in a sentence https://crown-associates.com

Fawn Creek Township, KS - Niche

WebThe most recent addition to the human CLEC2 family is keratinocyte-associated C-type lectin (KACL or CLEC2A), whose expression is almost exclusively restricted to the skin, in marked contrast to the broad expression of other CLEC2 family members in … WebNov 29, 2007 · The C-type lectin-like domain (CTLD) of CLEC2A is most similar to the CTLD of LLT1 ( approximately 60% similarity). Like mouse CLEC2 family members Clr … WebMar 6, 2007 · Function. C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN ( PubMed: 18215137 ). After ligand activation, … effeminate boys who wear dresses

CLEC2A: a novel, alternatively spliced and skin ... - ResearchGate

Category:Interaction of C-type lectin-like receptors NKp65 and KACL …

Tags:Clec2 family

Clec2 family

CLEC2A C-type lectin domain family 2 member A [ (human)]

WebMay 15, 2014 · Key Points. CLEC-2 is necessary for lymphatic cell proliferation and lymph node anlage persistence after birth.Lack of CLEC-2 expression on megakaryocytes and p WebRather, at least some mouse NKRP1 receptors ligate members of the CLEC2 family with NKRP1 and CLEC2 genes interspersed in a distinct subregion of the NKC establishing a …

Clec2 family

Did you know?

WebMay 22, 2015 · Interactions between podoplanin (PDPN) and C-type lectin domain family 1 member B (commonly known as CLEC2) are crucial checkpoints for FRC development 24,25, as Pdpn −/− and Clec1b −/− ... WebMar 29, 2024 · CLEC-2 is the first member of the C-type lectin family of receptors identified to stimulate platelet aggregation through a tyrosine kinase-dependent pathway. (Review) …

Webmember of the human CLEC2 family of CTLRs. In contrast to the other CLEC2 family members AICL, CD69, and LLT1, KACL expres-sion is mostly restricted to skin. Here we show that KACL is a non– disulfide-linked homodimeric surface receptor and stimulates cyto-toxicity by human NK92MI cells. We identified the corresponding WebNational Center for Biotechnology Information

WebNov 29, 2007 · These C-type lectin-like receptors (CTLR) mostly are homo- or heterodimers of type II transmembrane proteins and contain a single extracellular C-type lectin-like …

WebJun 11, 2024 · CLEC2 is a Syk-CLR that is specifically expressed in human platelets. Human CLEC2 encodes a 229–amino acid type II transmembrane protein, comprising a C-type lectin domain in the C-terminus, and a single YxxL motif (hemITAM) in the intracellular domain located at the N-terminus [ 60, 61 ].

WebOct 15, 2009 · CLEC-2 is a C-type lectin-like type II transmembrane receptor that was originally identified in immune cells 13, 14 and only recently revealed to be expressed in … content market fitWebC-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene. [3] This gene encodes a member of the natural killer cell receptor C-type … effeminatedWebJan 1, 2008 · The most recent addition to the human CLEC2 family is keratinocyte-associated C-type lectin (KACL or CLEC2A), whose expression is almost exclusively … effeminate characteristics