Citrinin pathway

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August undefined, 2024

WebFeb 26, 2024 · When data mining was performed on citrinin targets, the top five functional descriptions were a cell’s response to an organic cyclic compound, the netrin–UNC5B … WebAug 31, 1987 · Despite the similarity in structures between citrinin and ochratoxin, the PKS (CitS) catalyzing of the first enzyme-free intermediate (redoxcitrinin) in the citrinin …

Mrhst4 gene, coding for NAD+-dependent deacetylase is involved …

WebAbstract ：Two cDNA subtractive libraries of Monascus were constructed by suppression subtractive hybridization(SSH) andscreened of correlative genes from the citrinin biosynthetic pathway in Monascus species. All clones in the two libraries weresequenced and the results were analyzed by bioinformatic softwares. WebCitrinin appears to be toxic by multiple pathways including inhibition of nucleic acid synthesis, inhibition of microtubule assembly and tubulin polymerization, alteration of … ion stations kentucky

Citrinin - an overview ScienceDirect Topics

WebCitrinin, which is biosynthesized from a pentaketide through the acetate–malonate pathway with three C 1-sources, causes renal damage in swine. It has also been … WebJun 1, 2007 · Abstract. The mycotoxin CTN (citrinin), a natural contaminant in foodstuffs and animal feeds, has cytotoxic and genotoxic effects on various mammalian cells. CTN … WebFurthermore, citrinin activates some important factors involved in apoptosis, including p21-activated protein kinase 2 (PAK2) dependent pathways, caspase-3 and -9, c-Jun N-terminal kinase (JNK) and it raises reactive oxygen species (ROS) . Caspase-3 is famous as an executioner caspase in apoptosis. on the go internet unlimited

Citrinin - an overview ScienceDirect Topics

WebThe application of Monascus is restricted by citrinin. So, it is important to explore the synthetic pathway of citrinin to completely inhibit the production of citrinin. In our previous study, we found that the protein encoded by the ctnF gene has a significant similarity to fructose-2,6-bisphosphatase (F26BPase). WebHence, many studies have focused on improving the ratio of monacolin K to citrinin through optimal cultivation or fermentation. Given that citrinin and monacolin K biosynthetic gene clusters are ... ion stationkeeping strategies geostationaryWebJun 18, 2009 · In vitro trials were conducted to evaluate the effect of Azadirachta indica (neem) extracts on mycelial growth, sporulation, morphology and ochratoxin A production by P. verrucosum and P. brevicompactum. The effect of neem oil extract from seeds and leaf was evaluated at 0.125; 0.25 and 0.5% and 6.25 and 12.5 mg/mL, respectively, in Yeast … ion station smoke alarm

"WebJan 1, 1999 · Biosynthesis of citrinin and synthesis of its biogenetic precursors L. Colombo, C. Gennari, D. Potenza, C. Scolastico, F. Aragozzini, C. Merendi Chemistry 1980 … " - Citrinin pathway

Citrinin pathway

Toxins Free Full-Text Effect of Neem Leaf Extract and Neem Oil …

WebMar 30, 2024 · The disruption of MPs biosynthesis pathway can increase the production of citrinin, which may be due to more initial and extension units for citrinin biosynthesis. This illustrated that blocking of citrinin or pigment biosynthesis could significantly cause a change in their production in M. purpureus , and there is a mutual regulation between ... WebUV-Vis scan and UPLC detection showed that disruption of Mrhst4 significantly increased the MonAzPs yields, and citrinin content was dramatically enhanced during the tested period. RT-qPCR results showed that the absence of Mrhst4 significantly increased the relative expression of citrinin biosynthetic pathway genes including pksCT, mrl1, mrl2 ...

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WebSep 29, 2011 · In the citrinin biosynthesis pathway, the transcriptional activator (ctnA) is one of the important components in the citrinin cluster [53]. According to our qRT-PCR analysis (Figure 3B), the ... WebJun 15, 2009 · Furthermore, co-exposure of HEK293 cells to CTN and MAPK pathway inhibitors demonstrated that CTN increased the levels of Gadd45{beta} mRNA through ERK1/2 signaling pathway and up-regulated the MMP3 transcripts majorly via …

WebOct 1, 2024 · The citrinin pathway belongs to the former as it is present in many Penicillium, Aspergillus, and Monascus species [30, 44, 45]. However, the biosynthetic gene cluster of Monascus azaphilone pigments is limited in the Monascus genera. The biosynthetic process of secondary metabolites forms a cluster or non-clustered gene … WebJun 28, 2024 · In addition, changes in transcription factor expression may also influence the network regulating the citrinin synthesis pathway in M. purpureus. Moreover, the yields of pigments produced by the ...

WebNational Center for Biotechnology Information WebSep 29, 2011 · CIT is synthesized via the polyketide pathway [20]. It is generally known that three secondary metabolites, pigments, monacolin K, and citrinin, share a biochemical …

WebKey Contribution: Optimal biomarkers for exposure were determined for OTA and CIT in pig serum and urine. The prolonged experiment after the exposure of the pigs to feed naturally contaminated with multiple mycotoxin (DON, ZEN, OTA and CIT) allowed to assess the kinetic pathway of mycotoxin biomarkers in pigs and demonstrated why biomonitoring is …

WebDec 6, 2014 · To learn more about the citrinin biosynthetic pathway, a ctnG-replacement vector was constructed to disrupt ctnG with the hygromycin resistance gene as the selection marker, then transformed into ... ions teWebYes. Some red yeast rice products contain a contaminant called citrinin, which is toxic and can damage the kidneys. In a 2024 analysis of 37 red yeast rice products, only one had citrinin levels below the maximum … ion stayWebJan 1, 2016 · Citrinin is a toxic secondary metabolite of Penicillium citrinum and its contamination in many food items has been widely reported. However, research on the citrinin biosynthesis pathway and its ... on the go joy bundle upWebJan 1, 2016 · The individual steps of citrinin 1 biosynthesis in Monascus ruber M7 were determined by a combination of targeted gene knockout and heterologous gene … on-the-go joy savvy bootWebFeb 21, 2024 · Citrinin is a toxic secondary metabolite of Penicillium citrinum and its contamination in many food items has been widely reported. However, research on the citrinin biosynthesis pathway and its regulation mechanism in P. citrinum is rarely reported. In this study, we investigated the effect of different carbon sources on citrinin production … ion statut moralWebTo learn more about the citrinin biosynthetic pathway, a ctnG-replacement vector was constructed to disrupt ctnG with the hygromycin resistance gene as the selection marker, then transformed into M. aurantiacus Li AS3.4384 by a protoplast-PEG method. The citrinin content of three disruptants was reduced to about 50%, meanwhile pigment ... ion sterian transgazWebMonascus aurantiacus produces high amounts of citrinin which is a mycotoxin with nephrotoxic activity. Six putative citrinin biosynthesis genes have been discovered in M. purpureus and at least 10 genes are responsible for its biosynthesis. However, the sequence of citrinin pathway gene cluster in M. aurantiacus has not been reported. on the go jack linkletter